Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL5959066

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
C=CC(=O)Nc1cc(N2CCN(C3CC3)CC2)ccc1Nc1cc(N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)ncn1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL5959066
Phase Preclinical
Structure Type MOL
InChI Key GTRUQMSGMBIRPQ-UHFFFAOYSA-N
4
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

641.6
MW (Da)
5.62
ALogP
9
HBA
3
HBD
124.2
PSA (Ų)
0.24
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H34Cl2N8O4
MW 641.56
Aromatic Rings 3
Heavy Atoms 44
NP-Likeness -1.03

Activity Summary

IC50 8 meas. best 8.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fibroblast growth factor receptor 4
CHEMBL3973
 IC50 8.6 8.6 2.5 2
Fibroblast growth factor receptor 1
CHEMBL3650
 IC50 6.21 6.21 618.0 2
Fibroblast growth factor receptor 2
CHEMBL4142
 IC50 6.19 6.19 644.0 2
Fibroblast growth factor receptor 3
CHEMBL2742
 IC50 6.06 6.06 880.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Fibroblast growth factor receptor 4 IC50 = 2.5 nM 8.6 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 4 IC50 = 2.5 nM 8.6 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 1 IC50 = 618.0 nM 6.21 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 1 IC50 = 618.0 nM 6.21 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 2 IC50 = 644.0 nM 6.19 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 2 IC50 = 644.0 nM 6.19 Determination of the Effect of the Compounds of the Present Invention Against FG... -
Fibroblast growth factor receptor 3 IC50 = 880.0 nM 6.06 Inhibition Assay: The experimental procedure is briefly described as follows: th... -
Fibroblast growth factor receptor 3 IC50 = 880.0 nM 6.06 Determination of the Effect of the Compounds of the Present Invention Against FG... -

Data from ChEMBL 36 via Core Engine