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Compound Detail

CHEMBL5962068

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COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(C(=O)NC4CCN(C5COC5)CC4)cc(C(C)(C)C)c3)c12

Basic Information

ChEMBL ID CHEMBL5962068
Phase Preclinical
Structure Type MOL
InChI Key QUGZCQSQJAUOTO-UHFFFAOYSA-N
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

622.8
MW (Da)
6.26
ALogP
8
HBA
2
HBD
118.4
PSA (Ų)
0.23
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C36H42N6O4
MW 622.77
Aromatic Rings 5
Heavy Atoms 46
NP-Likeness -0.87

Activity Summary

Ki 6 meas. best 8.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Bromodomain-containing protein 3
CHEMBL1795186
Ki 8.64 8.375 2.3 2
Bromodomain-containing protein 2
CHEMBL1293289
Ki 8.49 8.25 3.2 3
Bromodomain-containing protein 4
CHEMBL1163125
Ki 8.0 8.0 10.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine