Compound Detail
CHEMBL5976059
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Basic Information
| ChEMBL ID | CHEMBL5976059 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QJLTYACRBMYTNB-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
415.5
MW (Da)
1.47
ALogP
8
HBA
1
HBD
108.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
| Activin receptor type-1 CHEMBL5903 | IC50 | 5.9 | 5.9 | 1250.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 300.0 | nM | 6.52 | Enzymatic Assay: un-Phosphorylated (UP): The inhibitor potency of the exemplifie... | - |
| Activin receptor type-1 | IC50 | = | 1250.0 | nM | 5.9 | HTRF Assay (3 uM ATP): ALK2 (aa 147-end) was obtained from BPS biosciences. The ... | - |
| Activin receptor type-1 | IC50 | = | 1250.0 | nM | 5.9 | HTRF Assay (100 uM ATP): ALK2 (aa 147-end) was obtained from BPS biosciences. Th... | - |
Data from ChEMBL 36 via Core Engine