Compound Detail
CHEMBL5996762
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Basic Information
| ChEMBL ID | CHEMBL5996762 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZRXUGWAQKKELFJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
444.3
MW (Da)
3.04
ALogP
5
HBA
0
HBD
60.1
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | IC50 | 7.82 | 7.82 | 15.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 15.0 | nM | 7.82 | Standard cell-based calcium flux assay: NMDA receptors are ion channels that are... | - |
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 15.0 | nM | 7.82 | Biological Assay (standard): NMDA receptors are ion channels that are highly per... | - |
Data from ChEMBL 36 via Core Engine