Compound Detail
CHEMBL59992
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL59992 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OFRVVOZORYSDMF-AWEZNQCLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
270.3
MW (Da)
2.35
ALogP
4
HBA
3
HBD
53.5
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 8.17 | 7.53 | 6.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 6.7 | nM | 8.17 | In vitro high binding affinity towards Dopamine receptor D2 by the displacement ... | 10354409 |
| D(2) dopamine receptor | Ki | = | 130.0 | nM | 6.89 | In vitro low binding affinity towards Dopamine receptor D2 by the displacement o... | 10354409 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10354409 | 10.1021/jm990023s | D(2) dopamine receptor | 3 |
| 10354409 | 10.1021/jm990023s | 5-hydroxytryptamine receptor 1A | 1 |
| 10354409 | 10.1021/jm990023s | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine