Assay Detail
Binding
CHEMBL675973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]quinpirole radioligand in rat striatal membranes
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 45 | 8.74 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303556 | — | — | 1 | 9.85 |
| CHEMBL60265 | — | — | 1 | 9.82 |
| CHEMBL64553 | — | — | 1 | 9.70 |
| CHEMBL59752 | — | — | 1 | 9.68 |
| CHEMBL61671 | — | — | 1 | 9.64 |
| CHEMBL64466 | — | — | 1 | 9.62 |
| CHEMBL300571 | — | — | 1 | 9.40 |
| CHEMBL435182 | — | — | 1 | 9.39 |
| CHEMBL64524 | — | — | 1 | 9.36 |
| CHEMBL292253 | — | — | 1 | 9.26 |
| CHEMBL60548 | — | — | 1 | 9.22 |
| CHEMBL62290 | — | — | 1 | 9.20 |
| CHEMBL63491 | — | — | 1 | 9.20 |
| CHEMBL305585 | — | — | 1 | 9.19 |
| CHEMBL59750 | — | — | 1 | 9.19 |
| CHEMBL64574 | — | — | 1 | 9.18 |
| CHEMBL434407 | — | — | 1 | 9.12 |
| CHEMBL304894 | — | — | 1 | 9.08 |
| CHEMBL418510 | — | — | 1 | 9.08 |
| CHEMBL291459 | — | — | 1 | 9.07 |
| CHEMBL418681 | — | — | 1 | 9.03 |
| CHEMBL59500 | — | — | 1 | 8.89 |
| CHEMBL302000 | — | — | 1 | 8.85 |
| CHEMBL60185 | — | — | 1 | 8.72 |
| CHEMBL64238 | — | — | 1 | 8.70 |
| CHEMBL300316 | — | — | 1 | 8.68 |
| CHEMBL59501 | — | — | 1 | 8.59 |
| CHEMBL60783 | — | — | 1 | 8.52 |
| CHEMBL60900 | — | — | 1 | 8.51 |
| CHEMBL64508 | — | — | 1 | 8.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303556 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL60265 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL64553 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL59752 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL61671 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL64466 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL300571 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL435182 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL64524 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL292253 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL60548 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL63491 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL62290 | — | Ki | = | 0.63 | nM | 9.20 |
| CHEMBL305585 | — | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL59750 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL64574 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL434407 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL304894 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL418510 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL291459 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL418681 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL59500 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL302000 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL60185 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL64238 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL300316 | — | Ki | = | 2.08 | nM | 8.68 |
| CHEMBL59501 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL60783 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL60900 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL64508 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL64420 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL64798 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL59737 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL294538 | — | Ki | = | 6.34 | nM | 8.20 |
| CHEMBL59992 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL416856 | — | Ki | = | 6.93 | nM | 8.16 |
| CHEMBL294204 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL64134 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL64283 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL302436 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL64509 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL61665 | — | Ki | = | 17.4 | nM | 7.76 |
| CHEMBL60840 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL64345 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL60361 | — | Ki | = | 77.1 | nM | 7.11 |