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Compound Detail

CHEMBL601036

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Cc1ccccc1CC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2

Basic Information

ChEMBL ID CHEMBL601036
Phase Preclinical
Structure Type MOL
InChI Key IPPHWQIXUDIHFZ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

370.4
MW (Da)
2.68
ALogP
5
HBA
4
HBD
90.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H26N2O4
MW 370.45
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness 0.04

Activity Summary

EC50 2 meas. best 9.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 9.15 9.15 0.7 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 8.35 8.35 4.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20096576 10.1016/j.bmcl.2009.12.087 Beta-2 adrenergic receptor 2
20096576 10.1016/j.bmcl.2009.12.087 Beta-1 adrenergic receptor 2
20096576 10.1016/j.bmcl.2009.12.087 Cavia porcellus 1
20096576 10.1016/j.bmcl.2009.12.087 Unchecked 1

Data from ChEMBL 36 via Core Engine