Compound Detail
CHEMBL6017709
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C[Si](C)(C)[C@H]1CC[C@@H](NC(=O)Cc2nc3cnc4[nH]ccc4c3n2[C@H]2CC[C@H](CC#N)CC2)CC1
Basic Information
| ChEMBL ID | CHEMBL6017709 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KPTCYPFMDURAAD-PVPVSOICSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
490.7
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK1 CHEMBL2835 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Non-receptor tyrosine-protein kinase TYK2 CHEMBL3553 | IC50 | 8.06 | 8.06 | 8.7 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 7.26 | 7.26 | 54.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK1 | IC50 | = | 0.8 | nM | 9.1 | Enzymatic Inhibition Assay: 11-point dosing series were made for each compound b... | - |
| Tyrosine-protein kinase JAK2 | IC50 | = | 4.0 | nM | 8.4 | Enzymatic Inhibition Assay: 11-point dosing series were made for each compound b... | - |
| Non-receptor tyrosine-protein kinase TYK2 | IC50 | = | 8.7 | nM | 8.06 | Enzymatic Inhibition Assay: 11-point dosing series were made for each compound b... | - |
| Tyrosine-protein kinase JAK3 | IC50 | = | 54.3 | nM | 7.26 | Enzymatic Inhibition Assay: 11-point dosing series were made for each compound b... | - |
Data from ChEMBL 36 via Core Engine