Compound Detail
CHEMBL6024312
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Basic Information
| ChEMBL ID | CHEMBL6024312 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WUMMDJMYFAWMBN-GFCCVEGCSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
432.4
MW (Da)
2.15
ALogP
9
HBA
2
HBD
145.1
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK CHEMBL5251 | IC50 | 9.09 | 9.005 | 0.8 | 2 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.77 | 7.655 | 16.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase BTK | IC50 | = | 0.813 | nM | 9.09 | BTK Inhibitory Activity: With regard to the setting of the conditions for a meth... | - |
| Tyrosine-protein kinase BTK | IC50 | = | 1.19 | nM | 8.92 | Measurement of BTK Inhibitory Activity (In Vitro): In a condition set for a meth... | - |
| Epidermal growth factor receptor | IC50 | = | 16.9 | nM | 7.77 | Measurement of EGFR Inhibitory Activity: With regard to the setting of the condi... | - |
| Epidermal growth factor receptor | IC50 | = | 28.8 | nM | 7.54 | EGFR Inhibitory Activity: With regard to the setting of the conditions for a met... | - |
Data from ChEMBL 36 via Core Engine