Compound Detail
CHEMBL6031865
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Basic Information
| ChEMBL ID | CHEMBL6031865 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQMWTFPJNNPXAG-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
471.0
MW (Da)
5.14
ALogP
7
HBA
0
HBD
58.8
PSA (Ų)
0.36
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase CHEMBL2652 | Ki | 7.7 | 7.7 | 20.0 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | Ki | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Ki | = | 20.0 | nM | 7.7 | Proximity Ligation Assay: Isolated cardiomyocytes were washed twice in PBS at ro... | - |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Ki | = | 1800.0 | nM | 5.75 | Proximity Ligation Assay: Isolated cardiomyocytes were washed twice in PBS at ro... | - |
Data from ChEMBL 36 via Core Engine