Compound Detail
CHEMBL6035202
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Basic Information
| ChEMBL ID | CHEMBL6035202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWYXVTBJGUHMRR-UHFFFAOYSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
6.45
ALogP
4
HBA
2
HBD
79.7
PSA (Ų)
0.34
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 6 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 2 CHEMBL1293289 | Kd | 8.0 | 7.81 | 10.0 | 3 |
| Bromodomain-containing protein 3 CHEMBL1795186 | Kd | 7.96 | 7.865 | 11.0 | 2 |
| Bromodomain-containing protein 4 CHEMBL1163125 | Kd | 7.57 | 7.57 | 27.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 2 | Kd | = | 10.0 | nM | 8.0 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
| Bromodomain-containing protein 2 | Kd | = | 11.0 | nM | 7.96 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
| Bromodomain-containing protein 3 | Kd | = | 11.0 | nM | 7.96 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
| Bromodomain-containing protein 3 | Kd | = | 17.0 | nM | 7.77 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
| Bromodomain-containing protein 4 | Kd | = | 27.0 | nM | 7.57 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
| Bromodomain-containing protein 2 | Kd | = | 34.0 | nM | 7.47 | Biolayer Interferometry (BLI) Binding Assay: Biotin labeled BRD proteins (10 μg/... | - |
Data from ChEMBL 36 via Core Engine