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Compound Detail

CHEMBL6037066

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Nc1nnc(N2CCOC(CO)C2)c(-c2ccccc2)n1

Basic Information

ChEMBL ID CHEMBL6037066
Phase Preclinical
Structure Type MOL
InChI Key RDGDHIJBLJBHQT-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

287.3
MW (Da)
0.32
ALogP
7
HBA
2
HBD
97.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H17N5O2
MW 287.32
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -0.75

Activity Summary

Ki 2 meas. best 7.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL226
Ki 7.49 7.49 32.4 1
Adenosine receptor A2a
CHEMBL251
Ki 5.53 5.53 2951.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine