Compound Detail
CHEMBL6043032
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Basic Information
| ChEMBL ID | CHEMBL6043032 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MXSDIGYURCYKOV-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
453.9
MW (Da)
4.22
ALogP
8
HBA
1
HBD
85.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 9.9 | 9.9 | 0.1 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 9.1 | 9.1 | 0.8 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.8 | 7.8 | 15.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 0.126 | nM | 9.9 | FGFR2 (Enzymatic Assay): In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 0.501 | nM | 9.3 | FGFR3 (Enzymatic Assay): In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/m... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 0.794 | nM | 9.1 | FGFR1 (Enzymatic Assay): In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/m... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 2.0 | nM | 8.7 | FGFR4 (Enzymatic Assay): In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/m... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 15.8 | nM | 7.8 | KDR (VEGFR2) (Enzymatic Assay): In a final reaction volume of 30 μL, KDR (h) (15... | - |
Data from ChEMBL 36 via Core Engine