Compound Detail
CHEMBL6053094
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Fc1cc(F)cc(Nc2ncc(-c3cnn(C4CCNCC4)c3)c(Nc3ccc4c(c3)CNCC4)n2)c1
Basic Information
| ChEMBL ID | CHEMBL6053094 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YULMPWFRJYANBE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
502.6
MW (Da)
4.68
ALogP
8
HBA
4
HBD
91.7
PSA (Ų)
0.30
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor TYRO3 CHEMBL5314 | IC50 | 9.8 | 9.8 | 0.2 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | IC50 | 7.39 | 7.39 | 41.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase receptor TYRO3 | IC50 | = | 0.16 | nM | 9.8 | Verification on Inhibitory Activities of TAM Receptor Inhibiting Compounds on Ty... | - |
| Tyrosine-protein kinase receptor UFO | IC50 | = | 41.0 | nM | 7.39 | Verification on Inhibitory Activities of TAM Receptor Inhibiting Compounds on Ty... | - |
Data from ChEMBL 36 via Core Engine