Compound Detail
CHEMBL6055974
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Basic Information
| ChEMBL ID | CHEMBL6055974 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GFOJWGYPLGSKOJ-GOSISDBHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
408.5
MW (Da)
2.42
ALogP
8
HBA
1
HBD
110.1
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | Ki | 9.25 | 9.25 | 0.6 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | Ki | 8.03 | 8.03 | 9.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Ki | = | 0.56 | nM | 9.25 | Biochemical Inhibition Assay: The biochemical inhibition of four PI3K isoforms b... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Ki | = | 9.41 | nM | 8.03 | Biochemical Inhibition Assay: The biochemical inhibition of four PI3K isoforms b... | - |
Data from ChEMBL 36 via Core Engine