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Compound Detail

CHEMBL605691

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CCNC(=O)[C@H]1OC(n2cnc3c(N)nc(C#Cc4ccc(F)cc4)nc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL605691
Phase Preclinical
Structure Type MOL
InChI Key IVQJCRPENRVNSX-BITNSZHFSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

426.4
MW (Da)
-0.30
ALogP
9
HBA
4
HBD
148.4
PSA (Ų)
0.42
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H19FN6O4
MW 426.41
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness -0.17

Activity Summary

Ki 4 meas. best 7.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 7.09 7.09 81.4 2
Adenosine receptor A1
CHEMBL318
Ki 5.48 5.48 3312.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7739005 10.1021/jm00009a007 Adenosine receptor A2a 3
7739005 10.1021/jm00009a007 Adenosine receptor A1 2
11170643 10.1021/jm0003642 Adenosine receptor A1 1
11170643 10.1021/jm0003642 Adenosine receptor A2a 1
7739005 10.1021/jm00009a007 ADMET 1
7739005 10.1021/jm00009a007 Adenosine receptors; A1 & A2a 1

Data from ChEMBL 36 via Core Engine