Compound Detail
CHEMBL609015
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Basic Information
| ChEMBL ID | CHEMBL609015 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DQBPGZXXICPELN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
391.2
MW (Da)
4.07
ALogP
4
HBA
0
HBD
42.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 8.41 | 8.41 | 3.9 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.7 | 7.7 | 20.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 3.91 | nM | 8.41 | Inhibition of [125I]IMPY binding to amyloid beta (1 to 42) aggregates (unknown o... | - |
| Unchecked | Ki | = | 20.1 | nM | 7.7 | Displacement of [125I]IMPY from aggregated amyloid beta (1-42) by gamma counting | 19651517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19651517 | 10.1016/j.bmc.2009.07.020 | Unchecked | 3 |
| 19651517 | 10.1016/j.bmc.2009.07.020 | No relevant target | 1 |
| - | 10.1039/C3MD00189J | Amyloid-beta precursor protein | 1 |
Data from ChEMBL 36 via Core Engine