Assay Detail
Binding
CHEMBL3136098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]IMPY binding to amyloid beta (1 to 42) aggregates (unknown origin) by gamma counting
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel radioiodinated 1,3,4-oxadiazole derivatives with improved in vivo properties for SPECT imaging of -amyloid plaques
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.10 | 8.52 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78012 | — | — | 1 | 8.52 |
| CHEMBL609015 | — | — | 1 | 8.41 |
| CHEMBL3134121 | — | — | 2 | 7.87 |
| CHEMBL3134120 | — | — | 2 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78012 | — | Ki | = | 3.05 | nM | 8.52 |
| CHEMBL609015 | — | Ki | = | 3.91 | nM | 8.41 |
| CHEMBL3134121 | — | Ki | = | 13.6 | nM | 7.87 |
| CHEMBL3134120 | — | Ki | = | 24.8 | nM | 7.61 |
| CHEMBL3134121 | — | Inhibition | - | % | - | |
| CHEMBL3134120 | — | Inhibition | - | % | - |