Compound Detail
CHEMBL610644
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Basic Information
| ChEMBL ID | CHEMBL610644 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CUKHVEVYOJENQF-YNJARDAQSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
364.6
MW (Da)
0.46
ALogP
7
HBA
3
HBD
100.6
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human betaherpesvirus 5 CHEMBL371 | IC50 | 4.54 | 4.54 | 29000.0 | 1 |
| HFF CHEMBL614071 | IC50 | 4.51 | 4.51 | 31000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human betaherpesvirus 5 | IC50 | = | 29000.0 | nM | 4.54 | Inhibitory concentration against human cytomegalovirus (HCMV) in plaque reductio... | 2846837 |
| HFF | IC50 | = | 31000.0 | nM | 4.51 | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | 2846837 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2846837 | 10.1021/jm00119a006 | Human betaherpesvirus 5 | 1 |
| 2846837 | 10.1021/jm00119a006 | HFF | 1 |
| 2846837 | 10.1021/jm00119a006 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine