Compound Detail
CHEMBL6212
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c1ccc(C[n+]2ccc(NCCCCCCCCCCNc3cc[n+](Cc4ccccc4)c4ccccc34)c3ccccc32)cc1
Basic Information
| ChEMBL ID | CHEMBL6212 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JFTHHZLVWUKENE-UHFFFAOYSA-P |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
608.9
MW (Da)
9.31
ALogP
2
HBA
2
HBD
31.8
PSA (Ų)
0.08
QED
2
Ro5 Violations
17
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| Small conductance calcium-activated potassium channel protein 2 CHEMBL2547 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel | IC50 | = | 700.0 | nM | 6.16 | SKCa-blocking activity by its ability to inhibit after hyperpolarization (AHP) i... | 8558503 |
| Small conductance calcium-activated potassium channel protein 2 | IC50 | = | 700.0 | nM | 6.16 | Inhibitory concentration of compound required for SKCa blocking action was asses... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8558503 | 10.1021/jm950520i | Small conductance calcium-activated potassium channel | 1 |
| 8558503 | 10.1021/jm950520i | Unchecked | 1 |
| - | 10.1016/S0960-894X(96)00568-9 | Small conductance calcium-activated potassium channel protein 2 | 1 |
| - | 10.1016/S0960-894X(96)00568-9 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine