Assay Detail
Functional
CHEMBL805641
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound required for SKCa blocking action was assessed from its ability to inhibit After hyperpolarisation (AHP) in cultured rat sympathetic neurons
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 2 (CHEMBL2547) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Bis-quinolinium cyclophanes: A novel class of potent blockers of the apamin-sensitive Ca2+-activated K+ channel
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.66 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446445 | UCL-1530 | — | 1 | 7.10 |
| CHEMBL6207 | — | — | 1 | 7.05 |
| CHEMBL268556 | — | — | 1 | 6.96 |
| CHEMBL258254 | — | — | 1 | 6.82 |
| CHEMBL6266 | — | — | 1 | 6.77 |
| CHEMBL266885 | — | — | 1 | 6.75 |
| CHEMBL6361 | — | — | 1 | 6.72 |
| CHEMBL6354 | — | — | 1 | 6.54 |
| CHEMBL6356 | — | — | 1 | 6.51 |
| CHEMBL269729 | — | — | 1 | 6.42 |
| CHEMBL429017 | — | — | 1 | 6.39 |
| CHEMBL6315 | — | — | 1 | 6.35 |
| CHEMBL6212 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446445 | UCL-1530 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL6207 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL268556 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL258254 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL6266 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL266885 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL6361 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL6354 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL6356 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL269729 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL429017 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL6315 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL6212 | — | IC50 | = | 700.0 | nM | 6.16 |