Compound Detail
CHEMBL6356
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Nc1cc[n+](Cc2ccc3c(c2)Cc2cc(C[n+]4ccc(N)c5ccccc54)ccc2-3)c2ccccc12
Basic Information
| ChEMBL ID | CHEMBL6356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | USOMLPZSQWAHIS-UHFFFAOYSA-P |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
5.40
ALogP
2
HBA
2
HBD
59.8
PSA (Ų)
0.33
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.51
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
| Small conductance calcium-activated potassium channel protein 2 CHEMBL2547 | IC50 | 6.51 | 6.51 | 310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 2 | IC50 | = | 310.0 | nM | 6.51 | Inhibitory concentration of compound required for SKCa blocking action was asses... | - |
| Small conductance calcium-activated potassium channel | IC50 | = | 310.0 | nM | 6.51 | The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed... | 10669569 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10669569 | 10.1021/jm9902537 | Small conductance calcium-activated potassium channel | 2 |
| - | 10.1016/S0960-894X(96)00568-9 | Small conductance calcium-activated potassium channel protein 2 | 1 |
| - | 10.1016/S0960-894X(96)00568-9 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine