Compound Detail
CHEMBL446445
UCL-1530 Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
c1ccc2c(c1)c1cc[n+]2Cc2ccc(cc2)Cc2ccc(cc2)C[n+]2ccc(c3ccccc32)NCCCCCCCCCCN1
Basic Information
| ChEMBL ID | CHEMBL446445 |
| Name | UCL-1530 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SXDHPHPRCINSFL-QEXFJYHKSA-P |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
620.9
MW (Da)
9.21
ALogP
2
HBA
2
HBD
31.8
PSA (Ų)
0.17
QED
2
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Small conductance calcium-activated potassium channel protein 2 CHEMBL2547 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.58 | 5.58 | 2600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel protein 2 | IC50 | = | 80.0 | nM | 7.1 | Inhibitory concentration of compound required for SKCa blocking action was asses... | - |
| Small conductance calcium-activated potassium channel | IC50 | = | 80.0 | nM | 7.1 | The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed... | 10669569 |
| Unchecked | IC50 | = | 2600.0 | nM | 5.58 | Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes | 15225721 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10669569 | 10.1021/jm9902537 | Small conductance calcium-activated potassium channel | 2 |
| - | 10.1016/S0960-894X(96)00568-9 | Small conductance calcium-activated potassium channel protein 2 | 1 |
| - | 10.1016/S0960-894X(96)00568-9 | Rattus norvegicus | 1 |
| 15225721 | 10.1016/j.bmcl.2004.05.031 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine