Assay Detail
Binding
CHEMBL832853
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Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | Hepatocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Defining determinant molecular properties for the blockade of the apamin-sensitive SKCa channel in guinea-pig hepatocytes: the influence of polarizability and molecular geometry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.70 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525408 | APAMIN | — | 1 | 9.00 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 5.77 |
| CHEMBL446445 | UCL-1530 | — | 1 | 5.58 |
| CHEMBL1687 | — | — | 1 | 5.52 |
| CHEMBL1360 | ATRACURIUM | 4.0 | 1 | 5.52 |
| CHEMBL185073 | PANCURONIUM | 4.0 | 1 | 5.46 |
| CHEMBL1201219 | VECURONIUM | 4.0 | 1 | 5.35 |
| CHEMBL360055 | GALLAMINE | 4.0 | 1 | 4.92 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 4.14 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | - |
| CHEMBL170 | QUININE | 4.0 | 1 | - |
| CHEMBL227934 | STRYCHNINE | -1.0 | 1 | - |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | - |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | - |
| CHEMBL588619 | CINCHONINE | -1.0 | 1 | - |
| CHEMBL611480 | — | — | 1 | - |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | - |
| CHEMBL1086 | DIBUCAINE | 4.0 | 1 | - |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | - |
| CHEMBL105608 | HEXAMETHONIUM CHLORIDE | — | 1 | - |
| CHEMBL9324 | TETRYLAMMONIUM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525408 | APAMIN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL446445 | UCL-1530 | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1687 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1360 | ATRACURIUM | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL185073 | PANCURONIUM | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1201219 | VECURONIUM | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL360055 | GALLAMINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL43184 | AMINACRINE | IC50 | = | 120000.0 | nM | - |
| CHEMBL170 | QUININE | IC50 | = | 150000.0 | nM | - |
| CHEMBL227934 | STRYCHNINE | IC50 | = | 190000.0 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 200000.0 | nM | - |
| CHEMBL1294 | QUINIDINE | IC50 | = | 240000.0 | nM | - |
| CHEMBL588619 | CINCHONINE | IC50 | = | 370000.0 | nM | - |
| CHEMBL611480 | — | IC50 | = | 420000.0 | nM | - |
| CHEMBL1190 | DECAMETHONIUM | IC50 | = | 450000.0 | nM | - |
| CHEMBL1086 | DIBUCAINE | IC50 | = | 470000.0 | nM | - |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 970000.0 | nM | - |
| CHEMBL105608 | HEXAMETHONIUM CHLORIDE | IC50 | = | 2000000.0 | nM | - |
| CHEMBL9324 | TETRYLAMMONIUM | IC50 | = | 7900000.0 | nM | - |