Compound Detail
CHEMBL63698
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Basic Information
| ChEMBL ID | CHEMBL63698 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZYFOKXDBHHJLB-IUCAKERBSA-N |
5
Targets
15
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
228.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 15 meas. best 7.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 7.36 | 6.58 | 44.0 | 2 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 4.92 | 4.92 | 12000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 44.0 | nM | 7.36 | In vitro for inhibition of Dipeptidylpeptidase IV. | 8642568 |
| Dipeptidyl peptidase 2 | IC50 | = | 1000.0 | nM | 6.0 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Unchecked | IC50 | = | 1100.0 | nM | 5.96 | EnPlex (purified enzyme activity assay): This assay is described in Bachovchin e... | - |
| Dipeptidyl peptidase 4 | IC50 | = | 1600.0 | nM | 5.8 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 9 | IC50 | = | 8500.0 | nM | 5.07 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 8 | IC50 | = | 12000.0 | nM | 4.92 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8642568 | 10.1021/jm950732f | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine