Compound Detail
CHEMBL63726
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Basic Information
| ChEMBL ID | CHEMBL63726 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NCKFTUHNPCXRDM-IUCAKERBSA-N |
6
Targets
15
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
243.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 15 meas. best 7.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 7.02 | 6.455 | 95.0 | 2 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 4.09 | 4.09 | 82000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 95.0 | nM | 7.02 | In vitro for inhibition of Dipeptidylpeptidase IV. | 8642568 |
| Dipeptidyl peptidase 2 | IC50 | = | 200.0 | nM | 6.7 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Unchecked | IC50 | = | 420.0 | nM | 6.38 | EnPlex (purified enzyme activity assay): This assay is described in Bachovchin e... | - |
| Dipeptidyl peptidase 4 | IC50 | = | 1300.0 | nM | 5.89 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 9 | IC50 | = | 1600.0 | nM | 5.8 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 8 | IC50 | = | 14000.0 | nM | 4.85 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Prolyl endopeptidase FAP | IC50 | = | 82000.0 | nM | 4.09 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8642568 | 10.1021/jm950732f | Dipeptidyl peptidase 4 | 1 |
Data from ChEMBL 36 via Core Engine