Compound Detail
CHEMBL65192
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Basic Information
| ChEMBL ID | CHEMBL65192 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YNZFFALZMRAPHQ-HOHBBMLPSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
376.6
MW (Da)
5.66
ALogP
3
HBA
3
HBD
60.7
PSA (Ų)
0.46
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.43
EC50 1 meas. best 8.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL3037 | Ki | 9.43 | 9.43 | 0.4 | 1 |
| Cannabinoid receptor CHEMBL2111385 | Ki | 8.7 | 8.7 | 2.0 | 1 |
| Cannabinoid receptor 1 CHEMBL3037 | EC50 | 8.12 | 8.12 | 7.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 0.37 | nM | 9.43 | Competition Receptor Binding Assay: Competition receptor binding was performed a... | - |
| Cannabinoid receptor | Ki | = | 2.0 | nM | 8.7 | Compound was evaluated for the competitive inhibition of [3H]3-(1,1-Dimethyl-hep... | 1317925 |
| Cannabinoid receptor 1 | EC50 | = | 7.5 | nM | 8.12 | [35S]GTPγS Binding Assay: [35S]GTPγS binding was performed as previously describ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1317925 | 10.1021/jm00089a018 | Cannabinoid receptor | 1 |
Data from ChEMBL 36 via Core Engine