Compound Detail
CHEMBL69507
NORMELINONINE F Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL69507 |
| Name | NORMELINONINE F |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UDHBHTHWWOQPBW-UHFFFAOYSA-O |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
183.2
MW (Da)
2.15
ALogP
0
HBA
1
HBD
19.7
PSA (Ų)
0.52
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
| Cholinesterase CHEMBL1914 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
| Acetylcholinesterase CHEMBL220 | IC50 | 5.39 | 5.39 | 4100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 340.0 | nM | 6.47 | Antiparasitic activity against Plasmodium falciparum K1 | 20133138 |
| Cholinesterase | IC50 | = | 800.0 | nM | 6.1 | Inhibition of BuChE (unknown origin) | 33528252 |
| Acetylcholinesterase | IC50 | = | 4100.0 | nM | 5.39 | Inhibition of AChE (unknown origin) by Ellman's method | 33528252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80774-5 | Acetylcholinesterase | 2 |
| 2374149 | 10.1021/jm00170a029 | Sodium-dependent dopamine transporter | 2 |
| - | 10.1016/S0960-894X(01)80774-5 | GABA-A receptor; anion channel | 1 |
| - | 10.1016/S0960-894X(01)80774-5 | Muscarinic acetylcholine receptor | 1 |
| 20133138 | 10.1016/j.bmc.2010.01.013 | Plasmodium falciparum | 1 |
| 20133138 | 10.1016/j.bmc.2010.01.013 | ADMET | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Cholinesterase | 1 |
| 33528252 | 10.1021/acs.jmedchem.0c01887 | Acetylcholinesterase | 1 |
Data from ChEMBL 36 via Core Engine