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Compound Detail

CHEMBL71783

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O=C(NCC#CCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL71783
Phase Preclinical
Structure Type MOL
InChI Key NZDBRYJVPWCALT-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

402.3
MW (Da)
3.55
ALogP
3
HBA
1
HBD
35.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H21Cl2N3O
MW 402.33
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -1.56

Activity Summary

Ki 2 meas. best 6.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(3) dopamine receptor
CHEMBL3138
Ki 6.41 6.41 394.0 1
D(2) dopamine receptor
CHEMBL339
Ki 5.77 5.77 1700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
12798330 10.1016/s0960-894x(03)00389-5 D(3) dopamine receptor 1
12798330 10.1016/s0960-894x(03)00389-5 D(2) dopamine receptor 1
12798330 10.1016/s0960-894x(03)00389-5 Dopamine receptor D2 and D3 1
12798330 10.1016/s0960-894x(03)00389-5 No relevant target 1

Data from ChEMBL 36 via Core Engine