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Assay Detail

CHEMBL672948

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards rat Dopamine receptor D2 in Sf9 cells expressing in recombinant baculovirus (Bv) using [125I]IABN as radioligand
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type Sf9
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.
Newman AH, Cao J, Bennett CJ, Robarge MJ, Freeman RA, Luedtke RR.
Bioorg Med Chem Lett (2003) 13 : 2179 -2183
PubMed 12798330 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 6.83 7.97

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL305019 1 7.97
CHEMBL71865 1 7.70
CHEMBL68720 1 7.45
CHEMBL71327 1 7.30
CHEMBL307800 1 7.26
CHEMBL69451 1 7.24
CHEMBL71502 1 7.10
CHEMBL68740 1 7.08
CHEMBL306672 1 7.06
CHEMBL304766 1 7.06
CHEMBL302374 1 7.06
CHEMBL69717 1 6.99
CHEMBL69571 1 6.97
CHEMBL262724 1 6.96
CHEMBL305294 1 6.87
CHEMBL301242 1 6.82
CHEMBL309118 1 6.82
CHEMBL304605 1 6.70
CHEMBL68860 1 6.60
CHEMBL69718 1 6.42
CHEMBL67750 1 6.40
CHEMBL71416 1 6.05
CHEMBL300780 1 6.04
CHEMBL71364 1 6.00
CHEMBL302796 1 5.99
CHEMBL71783 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL305019 Ki = 10.7 nM 7.97
CHEMBL71865 Ki = 20.0 nM 7.70
CHEMBL68720 Ki = 35.3 nM 7.45
CHEMBL71327 Ki = 50.1 nM 7.30
CHEMBL307800 Ki = 55.2 nM 7.26
CHEMBL69451 Ki = 57.9 nM 7.24
CHEMBL71502 Ki = 79.3 nM 7.10
CHEMBL68740 Ki = 83.2 nM 7.08
CHEMBL306672 Ki = 86.4 nM 7.06
CHEMBL304766 Ki = 87.3 nM 7.06
CHEMBL302374 Ki = 87.5 nM 7.06
CHEMBL69717 Ki = 102.0 nM 6.99
CHEMBL69571 Ki = 106.0 nM 6.97
CHEMBL262724 Ki = 109.4 nM 6.96
CHEMBL305294 Ki = 134.0 nM 6.87
CHEMBL301242 Ki = 150.0 nM 6.82
CHEMBL309118 Ki = 153.0 nM 6.82
CHEMBL304605 Ki = 198.0 nM 6.70
CHEMBL68860 Ki = 250.0 nM 6.60
CHEMBL69718 Ki = 376.0 nM 6.42
CHEMBL67750 Ki = 396.0 nM 6.40
CHEMBL71416 Ki = 891.0 nM 6.05
CHEMBL300780 Ki = 911.0 nM 6.04
CHEMBL71364 Ki = 1000.0 nM 6.00
CHEMBL302796 Ki = 1020.0 nM 5.99
CHEMBL71783 Ki = 1700.0 nM 5.77