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Compound Detail

CHEMBL78866

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CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc(SC)c2C(=O)O)cc1

Basic Information

ChEMBL ID CHEMBL78866
Phase Preclinical
Structure Type MOL
InChI Key GBZHQPCAGQMJRB-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

558.7
MW (Da)
5.15
ALogP
7
HBA
3
HBD
130.4
PSA (Ų)
0.20
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H34N4O5S2
MW 558.73
Aromatic Rings 3
Heavy Atoms 38
NP-Likeness -1.19

Activity Summary

IC50 3 meas. best 9.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
IC50 9.7 9.7 0.2 2
Angiotensin II receptor
CHEMBL2094256
IC50 7.01 7.01 97.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
7608902 10.1021/jm00013a013 Angiotensin II receptor (AT-1) type-1 3
- 10.1016/0960-894X(95)00478-C Angiotensin II receptor 3
- 10.1016/0960-894X(95)00478-C Angiotensin II receptor (AT-1) type-1 1

Data from ChEMBL 36 via Core Engine