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Compound Detail

CHEMBL84686

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CCCCc1nc(SC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NCC2CCCCC2)cc1

Basic Information

ChEMBL ID CHEMBL84686
Phase Preclinical
Structure Type MOL
InChI Key APPXUHSHUNYXAJ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

598.8
MW (Da)
5.93
ALogP
7
HBA
3
HBD
130.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H38N4O5S2
MW 598.79
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -1.10

Activity Summary

IC50 2 meas. best 10.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Angiotensin II receptor (AT-1) type-1
CHEMBL2094250
IC50 10.0 10.0 0.1 1
Angiotensin II receptor
CHEMBL2094256
IC50 7.77 7.77 17.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00478-C Angiotensin II receptor 3
- 10.1016/0960-894X(95)00478-C Angiotensin II receptor (AT-1) type-1 1

Data from ChEMBL 36 via Core Engine