Compound Detail
CHEMBL84952
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Basic Information
| ChEMBL ID | CHEMBL84952 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QQONDLJPUIDYFZ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
375.3
MW (Da)
6.17
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.46
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon receptor CHEMBL1985 | IC50 | 5.66 | 5.66 | 2200.0 | 1 |
| MAP kinase p38 CHEMBL2094115 | IC50 | 5.66 | 5.66 | 2200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase p38 | IC50 | = | 2200.0 | nM | 5.66 | Binding affinity towards human Mitogen-activated protein kinase p38 expressed as... | 11549467 |
| Glucagon receptor | IC50 | = | 2200.0 | nM | 5.66 | Inhibition of human glucagon receptor expressed in CHO cell membranes by radioli... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17079151 | 10.1016/j.bmc.2006.10.025 | Mus musculus | 10 |
| 11549467 | 10.1016/s0960-894x(01)00498-x | Glucagon receptor | 1 |
| 11549467 | 10.1016/s0960-894x(01)00498-x | MAP kinase p38 | 1 |
| 17079151 | 10.1016/j.bmc.2006.10.025 | Rattus norvegicus | 1 |
| - | 10.1007/s00044-013-0869-9 | Glucagon receptor | 1 |
| 33479606 | 10.1039/c9md00468h | HeLa | 1 |
| 33479606 | 10.1039/c9md00468h | Plasmodium falciparum | 1 |
| 33479606 | 10.1039/c9md00468h | Hemozoin | 1 |
Data from ChEMBL 36 via Core Engine