Assay Detail
Binding
CHEMBL732095
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Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Substituted imidazoles as glucagon receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.74 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84759 | — | — | 1 | 7.70 |
| CHEMBL85009 | — | — | 1 | 7.64 |
| CHEMBL312928 | — | — | 1 | 7.40 |
| CHEMBL315836 | — | — | 1 | 7.30 |
| CHEMBL17736 | — | — | 1 | 7.16 |
| CHEMBL278041 | SB-202190 | — | 1 | 7.10 |
| CHEMBL314238 | — | — | 1 | 7.10 |
| CHEMBL420232 | — | — | 1 | 7.05 |
| CHEMBL87365 | — | — | 1 | 7.05 |
| CHEMBL276063 | — | — | 1 | 7.00 |
| CHEMBL84373 | — | — | 1 | 7.00 |
| CHEMBL314181 | — | — | 1 | 7.00 |
| CHEMBL316264 | — | — | 1 | 7.00 |
| CHEMBL312825 | — | — | 1 | 7.00 |
| CHEMBL84917 | — | — | 1 | 6.96 |
| CHEMBL17370 | — | — | 1 | 6.92 |
| CHEMBL87858 | — | — | 1 | 6.89 |
| CHEMBL416169 | — | — | 1 | 6.89 |
| CHEMBL315311 | — | — | 1 | 6.85 |
| CHEMBL314701 | — | — | 1 | 6.82 |
| CHEMBL85534 | — | — | 1 | 6.82 |
| CHEMBL87588 | — | — | 1 | 6.80 |
| CHEMBL87248 | — | — | 1 | 6.72 |
| CHEMBL17396 | — | — | 1 | 6.68 |
| CHEMBL85807 | — | — | 1 | 6.66 |
| CHEMBL315613 | — | — | 1 | 6.60 |
| CHEMBL86250 | — | — | 1 | 6.55 |
| CHEMBL85741 | — | — | 1 | 6.52 |
| CHEMBL17722 | — | — | 1 | 6.52 |
| CHEMBL314652 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84759 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL85009 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL312928 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL315836 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL17736 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL278041 | SB-202190 | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL314238 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL420232 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL87365 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL314181 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL312825 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL316264 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL84373 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL276063 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL84917 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL17370 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL87858 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL416169 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL315311 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL85534 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL314701 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL87588 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL87248 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL17396 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL85807 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL315613 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL86250 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL85741 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL17722 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL314652 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL88045 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL87611 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL85713 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL88044 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL84952 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL316361 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL85102 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL84840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL315800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL315828 | — | IC50 | > | 1000.0 | nM | - |