Compound Detail
CHEMBL85713
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Basic Information
| ChEMBL ID | CHEMBL85713 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAAZVAITVNPXCO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
375.5
MW (Da)
5.68
ALogP
4
HBA
0
HBD
30.7
PSA (Ų)
0.43
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.07
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon receptor CHEMBL1985 | IC50 | 6.07 | 6.07 | 861.0 | 1 |
| MAP kinase p38 CHEMBL2094115 | IC50 | 6.07 | 6.07 | 860.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase p38 | IC50 | = | 860.0 | nM | 6.07 | Binding affinity towards human Mitogen-activated protein kinase p38 expressed as... | 11549467 |
| Glucagon receptor | IC50 | = | 860.99 | nM | 6.07 | Inhibition of human glucagon receptor expressed in CHO cell membranes by radioli... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11549467 | 10.1016/s0960-894x(01)00498-x | Glucagon receptor | 1 |
| 11549467 | 10.1016/s0960-894x(01)00498-x | MAP kinase p38 | 1 |
| - | 10.1007/s00044-013-0869-9 | Glucagon receptor | 1 |
Data from ChEMBL 36 via Core Engine