Compound Detail
CHEMBL8674
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Basic Information
| ChEMBL ID | CHEMBL8674 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CANPFCFJURGKAX-SNVBAGLBSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
404.2
MW (Da)
2.22
ALogP
4
HBA
2
HBD
61.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 7.52 | 7.52 | 30.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 30.3 | nM | 7.52 | Inhibitory constant against binding of [125I]- IBZM to rat striatal membrane | 2966245 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2966245 | 10.1021/jm00400a027 | D(2) dopamine receptor | 1 |
| 17417631 | 10.1038/nchembio873 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine