Assay Detail
Binding
CHEMBL678337
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Inhibitory constant against binding of [125I]- IBZM to rat striatal membrane
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dopamine D-2 receptor imaging radiopharmaceuticals: synthesis, radiolabeling, and in vitro binding of (R)-(+)- and (S)-(-)-3-iodo-2-hydroxy-6-methoxy-N- [(1-ethyl-2-pyrrolidinyl)methyl]benzamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.79 | 9.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 9.83 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 9.20 |
| CHEMBL1255588 | — | — | 1 | 9.07 |
| CHEMBL8674 | — | — | 1 | 7.52 |
| CHEMBL8945 | — | — | 1 | 7.51 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.53 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 6.45 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 0.149 | nM | 9.83 |
| CHEMBL267723 | IOLOPRIDE | Ki | = | 0.633 | nM | 9.20 |
| CHEMBL1255588 | — | Ki | = | 0.851 | nM | 9.07 |
| CHEMBL8674 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL8945 | — | Ki | = | 31.1 | nM | 7.51 |
| CHEMBL59 | DOPAMINE | Ki | = | 296.0 | nM | 6.53 |
| CHEMBL51 | KETANSERIN | Ki | = | 359.0 | nM | 6.45 |
| CHEMBL62 | SCH-23390 | Ki | = | 600.0 | nM | 6.22 |