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Compound Detail

CHEMBL90532

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CC[C@@H]1C(=O)N(C)C[C@@H]1Cc1cncn1C

Basic Information

ChEMBL ID CHEMBL90532
Phase Preclinical
Structure Type MOL
InChI Key WNYVRXJDBXLEMN-ONGXEEELSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

221.3
MW (Da)
1.08
ALogP
3
HBA
0
HBD
38.1
PSA (Ų)
0.77
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H19N3O
MW 221.30
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.41

Activity Summary

IC50 2 meas. best 5.34

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 5.34 5.34 4600.0 1
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 4.99 4.99 10200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M1 3
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor M3 2
1732522 10.1021/jm00079a002 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine