Compound Detail
CHEMBL94983
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CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC
Basic Information
| ChEMBL ID | CHEMBL94983 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | IEJDKICPBODJMQ-TYTHOBKFSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
925.1
MW (Da)
2.86
ALogP
9
HBA
10
HBD
291.0
PSA (Ų)
0.04
QED
2
Ro5 Violations
26
Rot. Bonds
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin-1 receptor CHEMBL252 | IC50 | 7.89 | 7.705 | 13.0 | 2 |
| Endothelin receptor type B CHEMBL4631 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin-1 receptor | IC50 | = | 13.0 | nM | 7.89 | Binding affinity against endothelin A receptor from rabbit renal vascular smooth... | 7636842 |
| Endothelin-1 receptor | IC50 | = | 30.0 | nM | 7.52 | Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular ... | 7636842 |
| Endothelin receptor type B | IC50 | = | 150.0 | nM | 6.82 | Binding affinity against endothelin B receptor rat cerebellar membranes. | 7636842 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7636842 | 10.1021/jm00015a003 | Endothelin-1 receptor | 2 |
| 7636842 | 10.1021/jm00015a003 | Endothelin receptor type B | 1 |
Data from ChEMBL 36 via Core Engine