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Compound Detail

CHEMBL95817

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CC(C)CC(NC(=O)c1ccccc1)[Si](O)(O)CC(C)C(=O)N1CCC[C@H]1C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL95817
Phase Preclinical
Structure Type MOL
InChI Key LWANWPZJHGQFSN-NXYGQSRBSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

436.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H32N2O6Si
MW 436.58

Activity Summary

IC50 1 meas. best 7.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Angiotensin-converting enzyme
CHEMBL4074
 IC50 7.85 7.85 14.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Angiotensin-converting enzyme IC50 = 14.0 nM 7.85 Inhibitory activity of compound against angiotensin I converting enzyme was dete... 15125946

Literature References

PubMed DOI Target Context # Activities
15125946 10.1016/j.bmcl.2004.03.042 Angiotensin-converting enzyme 1

Data from ChEMBL 36 via Core Engine