Assay Detail
Binding
CHEMBL648441
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Inhibitory activity of compound against angiotensin I converting enzyme was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95564 | — | — | 1 | 9.00 |
| CHEMBL95846 | — | — | 1 | 8.42 |
| CHEMBL309941 | — | — | 1 | 8.09 |
| CHEMBL95817 | — | — | 1 | 7.85 |
| CHEMBL442193 | — | — | 1 | 7.72 |
| CHEMBL93662 | — | — | 1 | 7.34 |
| CHEMBL328814 | — | — | 1 | 7.14 |
| CHEMBL95819 | — | — | 1 | 6.68 |
| CHEMBL328537 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95564 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL95846 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL309941 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL95817 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL442193 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL93662 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL328814 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL95819 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL328537 | — | IC50 | = | 3200.0 | nM | 5.50 |