Compound Detail
CHEMBL95846
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C[C@H](C[Si](O)(O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)[O-].[Na+]
Basic Information
| ChEMBL ID | CHEMBL95846 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QXXOXGZEMXKCHV-NIFMGCQOSA-M |
| Parent Compound | CHEMBL2097001 |
| Active Moiety | CHEMBL2097001 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 8.42 | 8.42 | 3.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 3.8 | nM | 8.42 | Inhibitory activity of compound against angiotensin I converting enzyme was dete... | 15125946 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15125946 | 10.1016/j.bmcl.2004.03.042 | Angiotensin-converting enzyme | 2 |
Data from ChEMBL 36 via Core Engine