Compound Detail
CHEMBL328814
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C[C@@H](C[Si](O)(O)[C@@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
Basic Information
| ChEMBL ID | CHEMBL328814 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BAUPNCSSOJSBCN-YYWHXJBOSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 72.0 | nM | 7.14 | Inhibitory activity of compound against angiotensin I converting enzyme was dete... | 15125946 |
| Angiotensin-converting enzyme | IC50 | = | 72.0 | nM | 7.14 | Inhibition of ACE | 21413808 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15125946 | 10.1016/j.bmcl.2004.03.042 | Angiotensin-converting enzyme | 2 |
| 21413808 | 10.1021/jm1013693 | Angiotensin-converting enzyme | 1 |
Data from ChEMBL 36 via Core Engine