Histone deacetylase 1 · SINGLE PROTEIN · Rattus norvegicus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt Q4QQW4. Use UniProt Q4QQW4 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q4QQW4 as the stable identity anchor, then attach disease evidence before program review.
Histone deacetylase 1
Review this target as Histone deacetylase 1, mapped to UniProt Q4QQW4. Sequence length is 482 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 1 as ChEMBL target CHEMBL2915, mapped to UniProt Q4QQW4. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histone deacetylase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q4QQW4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 1 |
| UniProt Accession | Q4QQW4 |
| Component Type | Protein |
| Sequence Length | 482 aa |
Histone deacetylase 1
Review this target as Histone deacetylase 1, mapped to UniProt Q4QQW4. Sequence length is 482 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5202398 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL360194 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL259517 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL140000 | 6.62 | IC50 | 240.0 | Preclinical |
| CHEMBL113003 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL261492 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL259708 | 6.23 | IC50 | 590.0 | Preclinical |
| CHEMBL259434 | 6.2 | IC50 | 630.0 | Preclinical |
| CHEMBL261272 | 5.78 | IC50 | 1680.0 | Preclinical |
| CHEMBL260080 | 5.68 | IC50 | 2110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 19 | 5.8 |
| single protein format | 1 | 1 | 8.3 |