Nicotinic acetylcholine receptor alpha-4/beta-2 · PROTEIN COMPLEX · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q9ERK7. Use UniProt Q9ERK7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9ERK7 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit beta-2
Review this target as Nicotinic acetylcholine receptor alpha-4/beta-2, mapped to UniProt Q9ERK7. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 501 aa.
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This review treats Nicotinic acetylcholine receptor alpha-4/beta-2 as ChEMBL target CHEMBL3301382, mapped to UniProt Q9ERK7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nicotinic acetylcholine receptor alpha-4/beta-2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
| UniProt | Q9ERK7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit beta-2 |
| UniProt Accession | Q9ERK7 |
| Component Type | Protein |
| Sequence Length | 501 aa |
Neuronal acetylcholine receptor subunit beta-2
Review this target as Nicotinic acetylcholine receptor alpha-4/beta-2, mapped to UniProt Q9ERK7. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 501 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3217150 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL1783888 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL1783886 | 8.74 | Ki | 1.8 | Preclinical |
| CHEMBL3 | 8.46 | Ki | 3.5 | Approved |
| CHEMBL3215819 | 8.01 | Ki | 9.8 | Preclinical |
| CHEMBL1783883 | 7.96 | Ki | 11.0 | Preclinical |
| CHEMBL1783881 | 7.8 | Ki | 16.0 | Preclinical |
| CHEMBL1782074 | 7.7 | Ki | 20.0 | Preclinical |
| CHEMBL1783884 | 7.62 | Ki | 24.0 | Preclinical |
| CHEMBL1783879 | 7.6 | Ki | 25.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 50 | 5.0 |
| cell membrane format | 2 | 13 | 8.0 |
| subcellular format | 2 | 10 | 5.6 |