Neuronal acetylcholine receptor subunit alpha-3/beta-4 · PROTEIN COMPLEX · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q8R493. Use UniProt Q8R493 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8R493 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit beta-4
Review this target as Neuronal acetylcholine receptor subunit alpha-3/beta-4, mapped to UniProt Q8R493. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-4. Sequence length is 495 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuronal acetylcholine receptor subunit alpha-3/beta-4 as ChEMBL target CHEMBL3885609, mapped to UniProt Q8R493. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Neuronal acetylcholine receptor subunit alpha-3/beta-4 |
| Target Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
| UniProt | Q8R493 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit beta-4 |
| UniProt Accession | Q8R493 |
| Component Type | Protein |
| Sequence Length | 495 aa |
Neuronal acetylcholine receptor subunit beta-4
Review this target as Neuronal acetylcholine receptor subunit alpha-3/beta-4, mapped to UniProt Q8R493. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-4. Sequence length is 495 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3 | 6.78 | Ki | 167.0 | Approved |
| CHEMBL3217150 | 6.4 | EC50 | 400.0 | Preclinical |
| CHEMBL1783886 | 5.62 | EC50 | 2400.0 | Preclinical |
| CHEMBL1783881 | 5.48 | EC50 | 3300.0 | Preclinical |
| CHEMBL1782074 | 5.25 | EC50 | 5600.0 | Preclinical |
| CHEMBL1783880 | 5.02 | EC50 | 9500.0 | Preclinical |
| CHEMBL1783883 | 4.8 | EC50 | 16000.0 | Preclinical |
| CHEMBL3215819 | 4.68 | EC50 | 21000.0 | Preclinical |
| CHEMBL1783882 | 4.55 | EC50 | 28000.0 | Preclinical |
| CHEMBL1783878 | 4.47 | EC50 | 34000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 12 | 5.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 1 | 6.8 |