Review anchor
Casein kinase 2
PROTEIN COMPLEX · Rattus norvegicus
As of 2026-09-13
Evidence Snapshot
Casein kinase 2
CHEMBL3988629
PROTEIN COMPLEX
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Casein kinase 2 as ChEMBL target CHEMBL3988629, mapped to UniProt P67874. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3988629
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P67874
Casein kinase II subunit beta
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Casein kinase 2 matters
Casein kinase 2 is reviewed as Casein kinase II subunit beta (UniProt P67874); the current evidence base includes 0 approved drugs, 22 compounds, and 6 assays, with lead potency reaching pChEMBL 7.4.
Protein context
Casein kinase II subunit beta
Casein kinase II subunit beta Sequence length is 215 aa.
Review this target as Casein kinase 2, mapped to UniProt P67874. ChEMBL maps the protein component as Casein kinase II subunit beta. Sequence length is 215 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt P67874
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 0 approved drugs, 22 compounds, and 6 assays for this target. The dominant activity type is IC50. CHEMBL373937 is the current potency anchor at pChEMBL 7.4.
Use CHEMBL373937 as the tractability anchor when discussing potency (pChEMBL 7.4).
Activity source · ChEMBL 36 via Core Engine
pChEMBL 7.4
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Casein kinase 2 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt P67874, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
22
Total Compounds
6
Total Assays
0
Approved Drugs
IC50: 23.0, KI: 7.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL373937
|
7.4 | Ki | — |
|
|
No preferred name
CHEMBL6246
|
7.4 | IC50 | Clinical |
|
|
No preferred name
CHEMBL273101
|
7.2 | Ki | — |
|
|
No preferred name
CHEMBL270724
|
7.1 | Ki | — |
|
|
No preferred name
CHEMBL273101
|
7.0 | IC50 | — |
Source Header