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Target Snapshot

CHEMBL4907 Target Snapshot

Cyclic nucleotide-gated channel alpha-1 · SINGLE PROTEIN · Bos taurus

7Compounds
2Assays
1Approved Drugs
14.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q00194. Use UniProt Q00194 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q00194 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cyclic nucleotide-gated channel alpha-1 as ChEMBL target CHEMBL4907, mapped to UniProt Q00194. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cyclic nucleotide-gated channel alpha-1
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL4907
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q00194
Cyclic nucleotide-gated channel alpha-1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cyclic nucleotide-gated channel alpha-1 is the right protein anchor across sources, using UniProt Q00194 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCyclic nucleotide-gated channel alpha-1
UniProt AccessionQ00194
Component TypeProtein
Sequence Length690 aa

Cyclic nucleotide-gated channel alpha-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cyclic nucleotide-gated channel alpha-1, mapped to UniProt Q00194. Sequence length is 690 aa.

Mapped IDQ00194
Review nameCyclic nucleotide-gated channel alpha-1
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

KD14.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1917652 10.52 Kd 0.03 Preclinical
CHEMBL3559600 7.13 Kd 74.0 Preclinical
CHEMBL195005 5.51 Kd 3100.0 Preclinical
CHEMBL698 5.17 Kd 6800.0 Approved
Distribution

pChEMBL Value Distribution

2
5.0
2
5.5
0
6.0
0
6.5
1
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
7
Tested Compounds
1
Assay Types
Binding — 2 assays, 7 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 7 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine