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Assay Detail

CHEMBL1000124

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 infected in human PBMCs
16
Total Activities
16
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.
Rao KV, Kasanah N, Wahyuono S, Tekwani BL, Schinazi RF, Hamann MT.
J Nat Prod (2004) 67 : 1314 -1318
PubMed 15332848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 5.47 6.23
Activity 1 - -
IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL612054 1 6.23
CHEMBL253548 6-Deoxymanzamine X 1 5.80
CHEMBL506416 MANZAMINE X 1 5.64
CHEMBL258020 NEO-KAULUAMINE 1 5.64
CHEMBL403233 MANZAMINE A 1 5.38
CHEMBL118640 IRCINOL A 1 5.37
CHEMBL332054 IRCINAL 1 5.17
CHEMBL399694 MANZAMINE F 1 5.14
CHEMBL399493 MANZAMINE E 1 4.88
CHEMBL448901 1 -
CHEMBL500612 1 -
CHEMBL501843 1 -
CHEMBL502434 1 -
CHEMBL448704 MANZAMINE J 1 -
CHEMBL267345 AMPHOTERICIN B 4.0 1 -
CHEMBL8 CIPROFLOXACIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL612054 EC50 = 590.0 nM 6.23
CHEMBL253548 6-Deoxymanzamine X EC50 = 1600.0 nM 5.80
CHEMBL506416 MANZAMINE X EC50 = 2300.0 nM 5.64
CHEMBL258020 NEO-KAULUAMINE EC50 = 2300.0 nM 5.64
CHEMBL403233 MANZAMINE A EC50 = 4200.0 nM 5.38
CHEMBL118640 IRCINOL A EC50 = 4300.0 nM 5.37
CHEMBL332054 IRCINAL EC50 = 6800.0 nM 5.17
CHEMBL399694 MANZAMINE F EC50 = 7300.0 nM 5.14
CHEMBL399493 MANZAMINE E EC50 = 13100.0 nM 4.88
CHEMBL448901 Activity - -
CHEMBL500612 EC50 - -
CHEMBL501843 EC50 - -
CHEMBL502434 EC50 - -
CHEMBL448704 MANZAMINE J EC50 - -
CHEMBL267345 AMPHOTERICIN B EC50 - -
CHEMBL8 CIPROFLOXACIN IC50 - -