Assay Detail
Binding
CHEMBL1016575
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Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2B receptor expressed in CHO cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.52 | 8.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10332 | — | — | 1 | 8.79 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 7.64 |
| CHEMBL494885 | — | — | 1 | 7.32 |
| CHEMBL273485 | — | — | 1 | 6.78 |
| CHEMBL495096 | — | — | 1 | 6.72 |
| CHEMBL451229 | — | — | 1 | 6.72 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 6.47 |
| CHEMBL492639 | — | — | 1 | 6.35 |
| CHEMBL522151 | — | — | 1 | 6.32 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 6.30 |
| CHEMBL493675 | — | — | 1 | 6.15 |
| CHEMBL495097 | — | — | 1 | 6.06 |
| CHEMBL523048 | — | — | 1 | 6.02 |
| CHEMBL492445 | — | — | 1 | 6.00 |
| CHEMBL493272 | — | — | 1 | 5.97 |
| CHEMBL492648 | — | — | 1 | 5.97 |
| CHEMBL442815 | — | — | 1 | 5.92 |
| CHEMBL492444 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10332 | — | Ki | = | 1.622 | nM | 8.79 |
| CHEMBL10316 | IDAZOXAN | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL494885 | — | Ki | = | 47.86 | nM | 7.32 |
| CHEMBL273485 | — | Ki | = | 165.96 | nM | 6.78 |
| CHEMBL495096 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL451229 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL495095 | ALLYPHENYLINE | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL492639 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL522151 | — | Ki | = | 478.63 | nM | 6.32 |
| CHEMBL128168 | BIPHENYLINE | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL493675 | — | Ki | = | 707.95 | nM | 6.15 |
| CHEMBL495097 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL523048 | — | Ki | = | 954.99 | nM | 6.02 |
| CHEMBL492445 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL493272 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL492648 | — | Ki | = | 1071.52 | nM | 5.97 |
| CHEMBL442815 | — | Ki | = | 1202.26 | nM | 5.92 |
| CHEMBL492444 | — | Ki | = | 1659.59 | nM | 5.78 |